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1For treatment of moderate to severe vasomotor symptomsvulval and vaginal atrophy associated with the menopausethe lowest dose and regimen that will control symptoms should be chosen and medication should be discontinued as promptly as possible.

Changes in vaginal bleeding pattern and abnormal withdrawal bleeding or flowbreakthrough bleedingspottingdysmenorrhea.

Safety and effectiveness in pediatric patients have not buy unisom australia been establishedLarge and repeated doses of estrogen over an extended period of time have been shown to accelerate epiphyseal closureresulting in short adult stature if treatment is initiated before the completion of physiologic puberty in normally developing childrenIn patients in whom bone growth is not completeperiodic monitoring of bone maturation and effects on epiphyseal centers is recommended.

3For treatment of breast cancerfor palliation onlyin appropriately selected women and men with metastatic disease.

Estrogens with or without progestins should not be used for the prevention of cardiovascular disease or dementia.

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